medical.rxnorm

Normalize and verify drug names against RxNorm, the canonical US drug vocabulary from the NIH. Two modes: term ("tylenol 500mg", brand or generic, typos tolerated) returns ranked RxCUI candidates with normalized names and match scores; rxcui returns the canonical concept (name, term type like IN=ingredient / SBD=branded drug / SCD=clinical drug, suppression flag) plus related concepts — active ingredients, brand names, and available dose forms. Use before writing prescriptions data, drug interactions queries, or pharmacy integrations: verify the drug exists and get its stable identifier instead of trusting model memory. Sibling: /api/medical/icd10 (diagnosis codes). Public-domain NIH data.

price

$0.0012 USDC per call

method

GET/api/medical/rxnorm

payment

x402 v2 · USDC on Base (EIP-3009) or Solana (SPL transfer)

auth

None. Sign the payment, retry with PAYMENT-SIGNATURE.

tier

Tier 0 — no paid upstream

Parameters

Name	Type	Description
`term`	string	Free-text drug name. Provide term or rxcui, not both. min 2 chars · max 200 chars
`rxcui`	string	match ^\d{1,8}$
`limit`	integer	min 1 · max 20

Code samples

cURLbash

# 1. Probe with no auth → 402 envelope with PaymentRequirements
curl -sS 'https://2s.io/api/medical/rxnorm?term=xx&rxcui=12345&limit=5'

# 2. Sign + retry with PAYMENT-SIGNATURE:
curl -sS 'https://2s.io/api/medical/rxnorm?term=xx&rxcui=12345&limit=5' \
  -H 'PAYMENT-SIGNATURE: <base64-json-payload>'

# Or use the canonical runner (handles probe → sign → retry):
#   EVM_PRIVATE_KEY=0x... node --env-file=.env.local \
#     --experimental-strip-types scripts/x402-pay.ts \
#     'https://2s.io/api/medical/rxnorm?term=xx&rxcui=12345&limit=5'

TypeScript / Node — @2sio/sdktypescript

import { TwoS } from '@2sio/sdk'

const client = new TwoS({
  privateKey: process.env.EVM_PRIVATE_KEY as `0x${string}`,
})

const result = await client.medical.rxnorm({
  "term": "xx",
  "rxcui": "12345",
  "limit": 5
})

console.log('endpoint:', result.endpoint)
console.log('cost:', result.costUsd, 'USDC')
console.log('tx:', result.settlement?.txHash)
console.log('data:', result.data)

Python — 2siopython

import os
from twosio import TwoS

client = TwoS(private_key=os.environ["EVM_PRIVATE_KEY"])

result = client.medical.rxnorm(term="xx", rxcui="12345", limit=5)

print("endpoint:", result.endpoint)
print("cost:", result.cost_usd, "USDC")
print("tx:", (result.settlement or {}).get("tx_hash"))
print("data:", result.data)

MCP — Claude Desktop / AgentKit / any MCP hostjson

// 1. Add @2sio/mcp to your MCP host config (Claude Desktop example below).
//    EVM_PRIVATE_KEY funds x402 payments per call.

// claude_desktop_config.json
{
  "mcpServers": {
    "2sio": {
      "command": "npx",
      "args": ["-y", "@2sio/mcp"],
      "env": { "EVM_PRIVATE_KEY": "0x..." }
    }
  }
}

// 2. Once the server is running, agents call this tool via standard MCP:

{
  "jsonrpc": "2.0",
  "id": 1,
  "method": "tools/call",
  "params": {
    "name": "medical.rxnorm",
    "arguments": {
      "term": "xx",
      "rxcui": "12345",
      "limit": 5
    }
  }
}

Response

Field	Type	Description
`ok`	boolean	one of: true
`items`	array
`total`	integer	Total matching rows upstream; null when unknown.
`source`	object
`meta`	object

Example response datajson

{
  "ok": true,
  "items": [
    {}
  ],
  "total": 1,
  "source": {
    "provider": "example",
    "url": "example",
    "license": "example"
  },
  "meta": {
    "mode": "search",
    "concept": {
      "rxcui": "example",
      "name": "example",
      "synonym": "example",
      "termType": "example",
      "suppressed": false
    },
    "related": [
      {
        "termType": "example",
        "concepts": [
          {
            "rxcui": "example",
            "name": "example"
          }
        ]
      }
    ]
  }
}

Discovery

/api/directory — full catalog of every endpoint
/openapi.json — OpenAPI 3.1 spec (per-op x-payment-info, x402Payment security)
/.well-known/x402 — machine-readable service descriptor for x402-aware crawlers
/.well-known/mcp/server-card.json — MCP SEP-1649 server card
/llms.txt — plain-text manifest for LLM ingestion

2s.io is x402-native. Every call is paid per-request from a USDC-funded EVM wallet on Base — no signup, no API keys, no monthly fees. Source code: github.com/2s-io/sdk.