medical.genetics

MedlinePlus Genetics (US National Library of Medicine) reference on a genetic condition or gene. Give a term (e.g. "cystic fibrosis", "BRCA1", "sickle cell") and get back the authoritative NLM record: the condition/gene name, a plain-language summary, the full set of sections (description, causes, frequency, inheritance, treatment), the inheritance pattern(s), related genes (with links), synonyms, and cross-references to other databases (OMIM, GTR, ICD-10-CM, …). Free, public-domain (NLM). Authoritative genetics reference an LLM cannot recite reliably — for clinical, patient-education, and research agents. Educational reference, not medical advice.

price
$0.0011 USDC per call
method
GET/api/medical/genetics
payment
x402 v2 · USDC on Base (EIP-3009) or Solana (SPL transfer)
auth
None. Sign the payment, retry with PAYMENT-SIGNATURE.
tier
Tier 0 — no paid upstream

Parameters

NameTypeDescription
termrequiredstringCondition or gene name.
min 2 chars · max 100 chars

Code samples

cURLbash
# 1. Probe with no auth → 402 envelope with PaymentRequirements
curl -sS 'https://2s.io/api/medical/genetics?term=xx'

# 2. Sign + retry with PAYMENT-SIGNATURE:
curl -sS 'https://2s.io/api/medical/genetics?term=xx' \
  -H 'PAYMENT-SIGNATURE: <base64-json-payload>'

# Or use the canonical runner (handles probe → sign → retry):
#   EVM_PRIVATE_KEY=0x... node --env-file=.env.local \
#     --experimental-strip-types scripts/x402-pay.ts \
#     'https://2s.io/api/medical/genetics?term=xx'
TypeScript / Node — @2sio/sdktypescript
import { TwoS } from '@2sio/sdk'

const client = new TwoS({
  privateKey: process.env.EVM_PRIVATE_KEY as `0x${string}`,
})

const result = await client.medical.genetics({
  "term": "xx"
})

console.log('endpoint:', result.endpoint)
console.log('cost:', result.costUsd, 'USDC')
console.log('tx:', result.settlement?.txHash)
console.log('data:', result.data)
Python — 2siopython
import os
from twosio import TwoS

client = TwoS(private_key=os.environ["EVM_PRIVATE_KEY"])

result = client.medical.genetics(term="xx")

print("endpoint:", result.endpoint)
print("cost:", result.cost_usd, "USDC")
print("tx:", (result.settlement or {}).get("tx_hash"))
print("data:", result.data)
MCP — Claude Desktop / AgentKit / any MCP hostjson
// 1. Add @2sio/mcp to your MCP host config (Claude Desktop example below).
//    EVM_PRIVATE_KEY funds x402 payments per call.

// claude_desktop_config.json
{
  "mcpServers": {
    "2sio": {
      "command": "npx",
      "args": ["-y", "@2sio/mcp"],
      "env": { "EVM_PRIVATE_KEY": "0x..." }
    }
  }
}

// 2. Once the server is running, agents call this tool via standard MCP:

{
  "jsonrpc": "2.0",
  "id": 1,
  "method": "tools/call",
  "params": {
    "name": "medical.genetics",
    "arguments": {
      "term": "xx"
    }
  }
}

Response

FieldTypeDescription
okboolean
one of: true
itemsarray
totalintegerTotal matching rows upstream; null when unknown.
sourceobject
Example response datajson
{
  "ok": true,
  "items": [
    {
      "query": {
        "term": "example",
        "type": "condition",
        "slug": "example"
      },
      "type": "condition",
      "name": "example",
      "summary": "example",
      "sections": [
        {
          "role": "example",
          "text": "example"
        }
      ],
      "inheritancePatterns": [
        "example"
      ],
      "relatedGenes": [
        {
          "symbol": "example",
          "url": "example"
        }
      ],
      "synonyms": [
        "example"
      ],
      "crossReferences": [
        {
          "db": "example",
          "key": "example"
        }
      ],
      "url": "example"
    }
  ],
  "total": 1,
  "source": {
    "provider": "example",
    "url": "example",
    "license": "example"
  }
}

Discovery

2s.io is x402-native. Every call is paid per-request from a USDC-funded EVM wallet on Base — no signup, no API keys, no monthly fees. Source code: github.com/2s-io/sdk.