medical.drug-price

Look up US drug pricing from CMS NADAC (National Average Drug Acquisition Cost) — the benchmark per-unit acquisition cost CMS surveys from retail pharmacies and publishes weekly. Pass ndc (11-digit National Drug Code) for an exact product, or name (drug name/description keyword, e.g. 'atorvastatin 10 mg') to search. Returns rows with the NDC, description, nadacPerUnit (USD per pricing unit), pricingUnit (EA/ML/GM), effectiveDate, OTC flag, and brand/generic classification — most recent effective date first. Real surveyed acquisition costs instead of model-guessed prices. Public domain; the current-year dataset is resolved automatically. NADAC is an acquisition-cost benchmark, not a retail or insured price.

price

$0.0014 USDC per call

method

GET/api/medical/drug-price

payment

x402 v2 · USDC on Base (EIP-3009) or Solana (SPL transfer)

auth

None. Sign the payment, retry with PAYMENT-SIGNATURE.

tier

Tier 0 — no paid upstream

Parameters

Name	Type	Description
`ndc`	string	min 3 chars · max 20 chars
`name`	string	min 2 chars · max 80 chars
`limit`	integer	min 1 · max 100

Code samples

cURLbash

# 1. Probe with no auth → 402 envelope with PaymentRequirements
curl -sS 'https://2s.io/api/medical/drug-price?ndc=xxx&name=xx&limit=1'

# 2. Sign + retry with PAYMENT-SIGNATURE:
curl -sS 'https://2s.io/api/medical/drug-price?ndc=xxx&name=xx&limit=1' \
  -H 'PAYMENT-SIGNATURE: <base64-json-payload>'

# Or use the canonical runner (handles probe → sign → retry):
#   EVM_PRIVATE_KEY=0x... node --env-file=.env.local \
#     --experimental-strip-types scripts/x402-pay.ts \
#     'https://2s.io/api/medical/drug-price?ndc=xxx&name=xx&limit=1'

TypeScript / Node — @2sio/sdktypescript

import { TwoS } from '@2sio/sdk'

const client = new TwoS({
  privateKey: process.env.EVM_PRIVATE_KEY as `0x${string}`,
})

const result = await client.medical.drugPrice({
  "ndc": "xxx",
  "name": "xx",
  "limit": 1
})

console.log('endpoint:', result.endpoint)
console.log('cost:', result.costUsd, 'USDC')
console.log('tx:', result.settlement?.txHash)
console.log('data:', result.data)

Python — 2siopython

import os
from twosio import TwoS

client = TwoS(private_key=os.environ["EVM_PRIVATE_KEY"])

result = client.medical.drug_price(ndc="xxx", name="xx", limit=1)

print("endpoint:", result.endpoint)
print("cost:", result.cost_usd, "USDC")
print("tx:", (result.settlement or {}).get("tx_hash"))
print("data:", result.data)

MCP — Claude Desktop / AgentKit / any MCP hostjson

// 1. Add @2sio/mcp to your MCP host config (Claude Desktop example below).
//    EVM_PRIVATE_KEY funds x402 payments per call.

// claude_desktop_config.json
{
  "mcpServers": {
    "2sio": {
      "command": "npx",
      "args": ["-y", "@2sio/mcp"],
      "env": { "EVM_PRIVATE_KEY": "0x..." }
    }
  }
}

// 2. Once the server is running, agents call this tool via standard MCP:

{
  "jsonrpc": "2.0",
  "id": 1,
  "method": "tools/call",
  "params": {
    "name": "medical.drug-price",
    "arguments": {
      "ndc": "xxx",
      "name": "xx",
      "limit": 1
    }
  }
}

Response

Field	Type	Description
`ok`	boolean	one of: true
`items`	array
`total`	integer	Total matching rows upstream; null when unknown.
`source`	object
`meta`	object

Example response datajson

{
  "ok": true,
  "items": [
    {
      "ndc": "example",
      "description": "example",
      "nadacPerUnit": 1,
      "pricingUnit": "example",
      "effectiveDate": "example",
      "otc": false,
      "classification": "example",
      "asOfDate": "example"
    }
  ],
  "total": 1,
  "source": {
    "provider": "example",
    "url": "example",
    "license": "example"
  },
  "meta": {
    "query": {
      "ndc": "example",
      "name": "example"
    },
    "datasetYear": "example",
    "total": 1
  }
}

Discovery

/api/directory — full catalog of every endpoint
/openapi.json — OpenAPI 3.1 spec (per-op x-payment-info, x402Payment security)
/.well-known/x402 — machine-readable service descriptor for x402-aware crawlers
/.well-known/mcp/server-card.json — MCP SEP-1649 server card
/llms.txt — plain-text manifest for LLM ingestion

2s.io is x402-native. Every call is paid per-request from a USDC-funded EVM wallet on Base — no signup, no API keys, no monthly fees. Source code: github.com/2s-io/sdk.