medical.drug-label

Authoritative FDA drug label (Structured Product Labeling). Give a drug name (brand, generic, or substance), or an exact NDC, RxCUI, or SPL set_id, and get back the FDA-approved label split into the sections agents need: boxed warning, indications and usage, dosage and administration, contraindications, warnings, adverse reactions, drug interactions, use in specific populations, pregnancy, mechanism of action, and active/inactive ingredients. Each record also carries identity metadata (brand/generic names, manufacturer, NDCs, RxCUIs, route, DEA schedule, OTC vs prescription) plus a hasBoxedWarning flag. Free, public-domain US government data. Point-in-time public records, not medical advice. Use for prescribing-support, pharmacy, and clinical agents that must read the real label rather than guess it.

price

$0.0018 USDC per call

method

GET/api/medical/drug-label

payment

x402 v2 · USDC on Base (EIP-3009) or Solana (SPL transfer)

auth

None. Sign the payment, retry with PAYMENT-SIGNATURE.

tier

Tier 0 — no paid upstream

Parameters

Name	Type	Description
`drug`	string	Drug name — brand, generic, or substance. min 2 chars · max 120 chars
`ndc`	string	Exact product NDC. min 3 chars · max 20 chars
`rxcui`	string	Exact RxNorm RxCUI. match ^\d{1,9}$
`setId`	string	Exact SPL set_id. min 8 chars · max 80 chars
`limit`	integer	Max labels returned. min 1 · max 25

Code samples

cURLbash

# 1. Probe with no auth → 402 envelope with PaymentRequirements
curl -sS 'https://2s.io/api/medical/drug-label?drug=xx&ndc=xxx&rxcui=12345&setId=xxxxxxxx&limit=1'

# 2. Sign + retry with PAYMENT-SIGNATURE:
curl -sS 'https://2s.io/api/medical/drug-label?drug=xx&ndc=xxx&rxcui=12345&setId=xxxxxxxx&limit=1' \
  -H 'PAYMENT-SIGNATURE: <base64-json-payload>'

# Or use the canonical runner (handles probe → sign → retry):
#   EVM_PRIVATE_KEY=0x... node --env-file=.env.local \
#     --experimental-strip-types scripts/x402-pay.ts \
#     'https://2s.io/api/medical/drug-label?drug=xx&ndc=xxx&rxcui=12345&setId=xxxxxxxx&limit=1'

TypeScript / Node — @2sio/sdktypescript

import { TwoS } from '@2sio/sdk'

const client = new TwoS({
  privateKey: process.env.EVM_PRIVATE_KEY as `0x${string}`,
})

const result = await client.medical.drugLabel({
  "drug": "xx",
  "ndc": "xxx",
  "rxcui": "12345",
  "setId": "xxxxxxxx",
  "limit": 1
})

console.log('endpoint:', result.endpoint)
console.log('cost:', result.costUsd, 'USDC')
console.log('tx:', result.settlement?.txHash)
console.log('data:', result.data)

Python — 2siopython

import os
from twosio import TwoS

client = TwoS(private_key=os.environ["EVM_PRIVATE_KEY"])

result = client.medical.drug_label(drug="xx", ndc="xxx", rxcui="12345", setId="xxxxxxxx", limit=1)

print("endpoint:", result.endpoint)
print("cost:", result.cost_usd, "USDC")
print("tx:", (result.settlement or {}).get("tx_hash"))
print("data:", result.data)

MCP — Claude Desktop / AgentKit / any MCP hostjson

// 1. Add @2sio/mcp to your MCP host config (Claude Desktop example below).
//    EVM_PRIVATE_KEY funds x402 payments per call.

// claude_desktop_config.json
{
  "mcpServers": {
    "2sio": {
      "command": "npx",
      "args": ["-y", "@2sio/mcp"],
      "env": { "EVM_PRIVATE_KEY": "0x..." }
    }
  }
}

// 2. Once the server is running, agents call this tool via standard MCP:

{
  "jsonrpc": "2.0",
  "id": 1,
  "method": "tools/call",
  "params": {
    "name": "medical.drug-label",
    "arguments": {
      "drug": "xx",
      "ndc": "xxx",
      "rxcui": "12345",
      "setId": "xxxxxxxx",
      "limit": 1
    }
  }
}

Response

Field	Type	Description
`query`	object
`totalCount`	number
`returned`	number
`hasBoxedWarning`	boolean
`labels`	array
`source`	object

Example response datajson

{
  "query": {
    "drug": "example",
    "ndc": "example",
    "rxcui": "example",
    "setId": "example",
    "limit": 1
  },
  "totalCount": 1,
  "returned": 1,
  "hasBoxedWarning": false,
  "labels": [
    {
      "setId": "example",
      "splId": "example",
      "effectiveTime": "example",
      "brandNames": [
        "example"
      ],
      "genericNames": [
        "example"
      ],
      "substanceNames": [
        "example"
      ],
      "manufacturerNames": [
        "example"
      ],
      "productNdc": [
        "example"
      ],
      "routes": [
        "example"
      ],
      "productType": "example",
      "rxcui": [
        "example"
      ],
      "deaSchedule": "example",
      "isOtc": false,
      "boxedWarning": "example",
      "indicationsAndUsage": "example",
      "dosageAndAdministration": "example",
      "contraindications": "example",
      "warnings": "example",
      "adverseReactions": "example",
      "drugInteractions": "example",
      "useInSpecificPopulations": "example",
      "pregnancy": "example",
      "mechanismOfAction": "example",
      "activeIngredient": "example",
      "inactiveIngredient": "example",
      "purpose": "example",
      "doNotUse": "example",
      "whenUsing": "example",
      "stopUse": "example",
      "description": "example"
    }
  ],
  "source": {
    "provider": "example",
    "url": "example",
    "license": "example"
  }
}

Discovery

/api/directory — full catalog of every endpoint
/openapi.json — OpenAPI 3.1 spec (per-op x-payment-info, x402Payment security)
/.well-known/x402 — machine-readable service descriptor for x402-aware crawlers
/.well-known/mcp/server-card.json — MCP SEP-1649 server card
/llms.txt — plain-text manifest for LLM ingestion

2s.io is x402-native. Every call is paid per-request from a USDC-funded EVM wallet on Base — no signup, no API keys, no monthly fees. Source code: github.com/2s-io/sdk.