clinical.study-detail

Full ClinicalTrials.gov study record by NCT id — the deep detail beyond clinical.trial-search's summary. Returns the brief + detailed description, status, phases, conditions, study design (allocation, intervention model, primary purpose, masking), enrollment, interventions, primary and secondary outcome measures (with time frames), full eligibility criteria (inclusion/exclusion text, sex, age range, healthy-volunteers, standard age groups), lead sponsor and collaborators, all facility locations (name, city, state, country), whether results are posted, and key dates. Free, public-domain (NIH NLM). Use clinical.trial-search to find an NCT id, then this for the complete protocol.

price
$0.0014 USDC per call
method
GET/api/clinical/study-detail
payment
x402 v2 · USDC on Base (EIP-3009) or Solana (SPL transfer)
auth
None. Sign the payment, retry with PAYMENT-SIGNATURE.
tier
Tier 0 — no paid upstream

Parameters

NameTypeDescription
nctIdrequiredstring
match ^NCT\d{8}$

Code samples

cURLbash
# 1. Probe with no auth → 402 envelope with PaymentRequirements
curl -sS 'https://2s.io/api/clinical/study-detail?nctId=example'

# 2. Sign + retry with PAYMENT-SIGNATURE:
curl -sS 'https://2s.io/api/clinical/study-detail?nctId=example' \
  -H 'PAYMENT-SIGNATURE: <base64-json-payload>'

# Or use the canonical runner (handles probe → sign → retry):
#   EVM_PRIVATE_KEY=0x... node --env-file=.env.local \
#     --experimental-strip-types scripts/x402-pay.ts \
#     'https://2s.io/api/clinical/study-detail?nctId=example'
TypeScript / Node — @2sio/sdktypescript
import { TwoS } from '@2sio/sdk'

const client = new TwoS({
  privateKey: process.env.EVM_PRIVATE_KEY as `0x${string}`,
})

const result = await client.clinical.studyDetail({
  "nctId": "example"
})

console.log('endpoint:', result.endpoint)
console.log('cost:', result.costUsd, 'USDC')
console.log('tx:', result.settlement?.txHash)
console.log('data:', result.data)
Python — 2siopython
import os
from twosio import TwoS

client = TwoS(private_key=os.environ["EVM_PRIVATE_KEY"])

result = client.clinical.study_detail(nctId="example")

print("endpoint:", result.endpoint)
print("cost:", result.cost_usd, "USDC")
print("tx:", (result.settlement or {}).get("tx_hash"))
print("data:", result.data)
MCP — Claude Desktop / AgentKit / any MCP hostjson
// 1. Add @2sio/mcp to your MCP host config (Claude Desktop example below).
//    EVM_PRIVATE_KEY funds x402 payments per call.

// claude_desktop_config.json
{
  "mcpServers": {
    "2sio": {
      "command": "npx",
      "args": ["-y", "@2sio/mcp"],
      "env": { "EVM_PRIVATE_KEY": "0x..." }
    }
  }
}

// 2. Once the server is running, agents call this tool via standard MCP:

{
  "jsonrpc": "2.0",
  "id": 1,
  "method": "tools/call",
  "params": {
    "name": "clinical.study-detail",
    "arguments": {
      "nctId": "example"
    }
  }
}

Response

FieldTypeDescription
okboolean
one of: true
itemsarray
totalintegerTotal matching rows upstream; null when unknown.
sourceobject
Example response datajson
{
  "ok": true,
  "items": [
    {
      "nctId": "example",
      "briefTitle": "example",
      "officialTitle": "example",
      "status": "example",
      "studyType": "example",
      "phases": [
        "example"
      ],
      "conditions": [
        "example"
      ],
      "briefSummary": "example",
      "detailedDescription": "example",
      "eligibility": {
        "criteria": "example",
        "sex": "example",
        "minimumAge": "example",
        "maximumAge": "example",
        "healthyVolunteers": false,
        "stdAges": [
          "example"
        ]
      },
      "design": {
        "allocation": "example",
        "interventionModel": "example",
        "primaryPurpose": "example",
        "masking": "example"
      },
      "enrollmentCount": 1,
      "interventions": [
        {
          "type": "example",
          "name": "example"
        }
      ],
      "primaryOutcomes": [
        {
          "measure": "example",
          "timeFrame": "example"
        }
      ],
      "secondaryOutcomes": [
        {
          "measure": "example",
          "timeFrame": "example"
        }
      ],
      "leadSponsor": "example",
      "collaborators": [
        "example"
      ],
      "locations": [
        {
          "facility": "example",
          "city": "example",
          "state": "example",
          "country": "example"
        }
      ],
      "hasResults": false,
      "startDate": "example",
      "completionDate": "example",
      "lastUpdatePostedDate": "example",
      "url": "example"
    }
  ],
  "total": 1,
  "source": {
    "provider": "example",
    "url": "example",
    "license": "example"
  }
}

Discovery

2s.io is x402-native. Every call is paid per-request from a USDC-funded EVM wallet on Base — no signup, no API keys, no monthly fees. Source code: github.com/2s-io/sdk.