bio.protein

Look up a protein in UniProtKB by accession (e.g. "P04637", "Q9Y6K9", "P0DTC2"). Returns the entry id, reviewed (Swiss-Prot) flag, recommended + alternative protein names, gene names, organism + taxid, sequence length and molecular weight, the curated function description, subcellular locations, Gene Ontology terms (id + term + aspect: biological_process / molecular_function / cellular_component), PDB structure ids, and keywords. Bioinformatics, structural biology, drug-target research, education. Gene-centric sibling: /api/bio/gene. CC-BY UniProt data.

price

$0.0014 USDC per call

method

GET/api/bio/protein

payment

x402 v2 · USDC on Base (EIP-3009) or Solana (SPL transfer)

auth

None. Sign the payment, retry with PAYMENT-SIGNATURE.

tier

Tier 0 — no paid upstream

Parameters

Name	Type	Description
`accession`required	string	min 2 chars · max 20 chars · match ^[A-Za-z0-9]+$

Code samples

cURLbash

# 1. Probe with no auth → 402 envelope with PaymentRequirements
curl -sS 'https://2s.io/api/bio/protein?accession=xx'

# 2. Sign + retry with PAYMENT-SIGNATURE:
curl -sS 'https://2s.io/api/bio/protein?accession=xx' \
  -H 'PAYMENT-SIGNATURE: <base64-json-payload>'

# Or use the canonical runner (handles probe → sign → retry):
#   EVM_PRIVATE_KEY=0x... node --env-file=.env.local \
#     --experimental-strip-types scripts/x402-pay.ts \
#     'https://2s.io/api/bio/protein?accession=xx'

TypeScript / Node — @2sio/sdktypescript

import { TwoS } from '@2sio/sdk'

const client = new TwoS({
  privateKey: process.env.EVM_PRIVATE_KEY as `0x${string}`,
})

const result = await client.bio.protein({
  "accession": "xx"
})

console.log('endpoint:', result.endpoint)
console.log('cost:', result.costUsd, 'USDC')
console.log('tx:', result.settlement?.txHash)
console.log('data:', result.data)

Python — 2siopython

import os
from twosio import TwoS

client = TwoS(private_key=os.environ["EVM_PRIVATE_KEY"])

result = client.bio.protein(accession="xx")

print("endpoint:", result.endpoint)
print("cost:", result.cost_usd, "USDC")
print("tx:", (result.settlement or {}).get("tx_hash"))
print("data:", result.data)

MCP — Claude Desktop / AgentKit / any MCP hostjson

// 1. Add @2sio/mcp to your MCP host config (Claude Desktop example below).
//    EVM_PRIVATE_KEY funds x402 payments per call.

// claude_desktop_config.json
{
  "mcpServers": {
    "2sio": {
      "command": "npx",
      "args": ["-y", "@2sio/mcp"],
      "env": { "EVM_PRIVATE_KEY": "0x..." }
    }
  }
}

// 2. Once the server is running, agents call this tool via standard MCP:

{
  "jsonrpc": "2.0",
  "id": 1,
  "method": "tools/call",
  "params": {
    "name": "bio.protein",
    "arguments": {
      "accession": "xx"
    }
  }
}

Response

Field	Type	Description
`protein`	object
`source`	object

Example response datajson

{
  "protein": {
    "accession": "example",
    "entryId": "example",
    "reviewed": false,
    "proteinName": "example",
    "alternativeNames": [
      "example"
    ],
    "genes": [
      "example"
    ],
    "organism": {
      "scientificName": "example",
      "commonName": "example",
      "taxid": 1
    },
    "lengthAa": 1,
    "molecularWeightDa": 1,
    "function": "example",
    "subcellularLocations": [
      "example"
    ],
    "goTerms": [
      {
        "id": "example",
        "term": "example",
        "aspect": "example"
      }
    ],
    "pdbStructures": [
      "example"
    ],
    "keywords": [
      "example"
    ],
    "uniprotUrl": "example"
  },
  "source": {
    "provider": "example",
    "url": "example",
    "license": "example"
  }
}

Discovery

/api/directory — full catalog of every endpoint
/openapi.json — OpenAPI 3.1 spec (per-op x-payment-info, x402Payment security)
/.well-known/x402 — machine-readable service descriptor for x402-aware crawlers
/.well-known/mcp/server-card.json — MCP SEP-1649 server card
/llms.txt — plain-text manifest for LLM ingestion

2s.io is x402-native. Every call is paid per-request from a USDC-funded EVM wallet on Base — no signup, no API keys, no monthly fees. Source code: github.com/2s-io/sdk.