bio.gene

Look up a gene by its official symbol (e.g. "TP53", "BRCA1", "CFTR") and organism (taxid, default 9606 = human), merging NCBI Gene with UniProt. Returns the gene symbol, NCBI Gene ID, full description, organism, chromosome + cytogenetic map location, alias symbols, and the curated RefSeq function summary; plus the reviewed protein from UniProt — accession, entry id, recommended protein name, length in amino acids, and the curated function description. NCBI + UniProt links. Bioinformatics, clinical-genetics research, education. Public-domain NCBI + CC-BY UniProt data. Common organism taxids: human 9606, mouse 10090, zebrafish 7955, fruit fly 7227, yeast 559292.

price

$0.0019 USDC per call

method

GET/api/bio/gene

payment

x402 v2 · USDC on Base (EIP-3009) or Solana (SPL transfer)

auth

None. Sign the payment, retry with PAYMENT-SIGNATURE.

tier

Tier 0 — no paid upstream

Parameters

Name	Type	Description
`symbol`required	string	min 1 chars · max 30 chars
`taxid`	integer	min 1 · max 9999999

Code samples

cURLbash

# 1. Probe with no auth → 402 envelope with PaymentRequirements
curl -sS 'https://2s.io/api/bio/gene?symbol=example&taxid=9606'

# 2. Sign + retry with PAYMENT-SIGNATURE:
curl -sS 'https://2s.io/api/bio/gene?symbol=example&taxid=9606' \
  -H 'PAYMENT-SIGNATURE: <base64-json-payload>'

# Or use the canonical runner (handles probe → sign → retry):
#   EVM_PRIVATE_KEY=0x... node --env-file=.env.local \
#     --experimental-strip-types scripts/x402-pay.ts \
#     'https://2s.io/api/bio/gene?symbol=example&taxid=9606'

TypeScript / Node — @2sio/sdktypescript

import { TwoS } from '@2sio/sdk'

const client = new TwoS({
  privateKey: process.env.EVM_PRIVATE_KEY as `0x${string}`,
})

const result = await client.bio.gene({
  "symbol": "example",
  "taxid": 9606
})

console.log('endpoint:', result.endpoint)
console.log('cost:', result.costUsd, 'USDC')
console.log('tx:', result.settlement?.txHash)
console.log('data:', result.data)

Python — 2siopython

import os
from twosio import TwoS

client = TwoS(private_key=os.environ["EVM_PRIVATE_KEY"])

result = client.bio.gene(symbol="example", taxid=9606)

print("endpoint:", result.endpoint)
print("cost:", result.cost_usd, "USDC")
print("tx:", (result.settlement or {}).get("tx_hash"))
print("data:", result.data)

MCP — Claude Desktop / AgentKit / any MCP hostjson

// 1. Add @2sio/mcp to your MCP host config (Claude Desktop example below).
//    EVM_PRIVATE_KEY funds x402 payments per call.

// claude_desktop_config.json
{
  "mcpServers": {
    "2sio": {
      "command": "npx",
      "args": ["-y", "@2sio/mcp"],
      "env": { "EVM_PRIVATE_KEY": "0x..." }
    }
  }
}

// 2. Once the server is running, agents call this tool via standard MCP:

{
  "jsonrpc": "2.0",
  "id": 1,
  "method": "tools/call",
  "params": {
    "name": "bio.gene",
    "arguments": {
      "symbol": "example",
      "taxid": 9606
    }
  }
}

Response

Field	Type	Description
`gene`	object
`sources`	array

Example response datajson

{
  "gene": {
    "symbol": "example",
    "ncbiGeneId": "example",
    "description": "example",
    "organism": {
      "scientificName": "example",
      "commonName": "example",
      "taxid": 1
    },
    "chromosome": "example",
    "mapLocation": "example",
    "aliases": [
      "example"
    ],
    "summary": "example",
    "protein": {
      "found": false,
      "uniprotAccession": "example",
      "uniprotId": "example",
      "name": "example",
      "lengthAa": 1,
      "function": "example"
    },
    "ncbiUrl": "example",
    "uniprotUrl": "example"
  },
  "sources": [
    {
      "provider": "example",
      "url": "example",
      "license": "example"
    }
  ]
}

Discovery

/api/directory — full catalog of every endpoint
/openapi.json — OpenAPI 3.1 spec (per-op x-payment-info, x402Payment security)
/.well-known/x402 — machine-readable service descriptor for x402-aware crawlers
/.well-known/mcp/server-card.json — MCP SEP-1649 server card
/llms.txt — plain-text manifest for LLM ingestion

2s.io is x402-native. Every call is paid per-request from a USDC-funded EVM wallet on Base — no signup, no API keys, no monthly fees. Source code: github.com/2s-io/sdk.